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SAHA induces immunogenic cell death in triple negative breast cancer cells and its efficacy is enhanced by SOCS3 functional replacement.
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DOI：10.1016/j.ejphar.2026.178960.png)
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Abstract
En 中文
• SAHA triggers immunogenic cell death in IL-6–high TNBC cells. • IL-6/SOCS3 imbalance limits HDAC inhibitor efficacy in TNBC. • SOCS3 mimetic suppresses STAT3 and overcomes resistance to SAHA. • Combination enhances apoptosis and sensitivity at sub-toxic doses. • Dual targeting boosts CD4+ T cell activation and tumor immunogenicity.
Keywords:
SAHA
triple negative breast cancer
immunogenic cell death
SOCS3
STAT3
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