Salivary pathobiont Klebsiella pneumoniae exacerbating periodontitis-related intestinal dyshomeostasis and accelerated metabolic syndrome

doi:10.1016/j.molimm.2026.04.002

Salivary pathobiont Klebsiella pneumoniae exacerbating periodontitis-related intestinal dyshomeostasis and accelerated metabolic syndrome

2026-04-11

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DOI：10.1016/j.molimm.2026.04.002

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• Periodontitis promotes oral pathogens’ colonization in the gut via the “oral-gut axis”. • Kp94 from periodontitis inhibits intestinal ILC3/IL-22 signaling, causing glucose disorders and worsening diabetes. • IL-22 treatment restores gut homeostasis and islet function damaged by Kp94, improving diabetes. • ILC3/IL-22 is a potential therapeutic target for periodontitis-associated diabetes.

Keywords:

Klebsiella pneumoniae

periodontitis

intestinal dyshomeostasis

IL-22

metabolic syndrome

Salivary pathobiont Klebsiella pneumoniae exacerbating periodontitis-related intestinal dyshomeostasis and accelerated metabolic syndrome

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