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Scintillator-based radiocatalytic superoxide radical production for long-term tumor DNA damage
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DOI：10.1039/d2bm00101b.png)
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Abstract
En 中文
Photocatalytic materials absorb photons ranging from the ultraviolet to near-infrared region to initiate photocatalytic reactions and have broad application prospects in various fields. However, high-energy ionizing radiations are rarely involved in photocatalytic research. In this study, we proposed a high-energy radiation-based photocatalysis method, namely radiocatalysis, and prepared a TiO2-coated lanthanide pyrosilicate scintillator (LnPS@TiO2) as the radiocatalytic material. The lanthanide pyrosilicate post-radiation scintillators can efficiently convert radiation energy into ultraviolet energy, which can be resonantly transferred to TiO2 to selectively generate high-yield superoxide radicals (O-2*(-)). Compared with traditional radiotherapy, this radiocatalytic process can significantly kill cancer cells while achieving longterm DNA damage by inhibiting the DNA self-repair process. Our research expands the energy response range of photocatalysis and is expected to extend radiocatalysis to the tumor treatment field.
Keywords:
IRON-SULFUR CLUSTERS
PHOTODYNAMIC THERAPY
NANOPARTICLES
RADIOTHERAPY
LIGHT
SEMICONDUCTOR
DEGRADATION
HYDROGEN
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