scLDM: a conditional diffusion framework for single-cell perturbation prediction

Boyang Wu

doi:10.1093/bioinformatics/btag727

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scLDM: a conditional diffusion framework for single-cell perturbation prediction

2026-09-28

DOI：10.1093/bioinformatics/btag727

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Abstract

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Accurate prediction of single-cell responses to external stimuli is pivotal for deciphering gene regulatory mechanisms and accelerating data-driven drug discovery. However, effectively capturing the complex, non-linear mapping between intrinsic cell states and external stimuli remains an open problem.

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