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Screening for hepatitis C in average and high-risk populations of Qatar using rapid point-of-care testing
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DOI：10.1177/2050640615580725.png)
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Abstract
En 中文
Background: Screening for hepatitis C has been found to be beneficial in high-risk individuals and baby boomers'. Objective: Our aim was to screen for hepatitis C in average and high-risk individuals and compare the disease characteristics and response to treatment among the screened group (SG) and non-screened group (NSG). Method: Community-based screening for hepatitis C was done in the average and high-risk populations of Qatar. Screening was done using rapid point-of-care testing. All patients with stage 1 fibrosis on liver biopsy were treated with pegylated interferon and ribavirin. Results: In total, 13,704 people were screened and 272 (2%, 95% CI (1.8-2.2%) had positive antibodies to hepatitis C. During the same period, 237 non-screened patients (NSG) with hepatitis C were referred for treatment. Alanine and aspartate aminotransferases (ALT, AST) and overall fibrosis were significantly lower in the SG as compared with the NSG (p=0.04, 0.04 and 0.01, respectively). The response to treatment was similar in the SG as compared with the NSG (sustained viral response 61.7 % versus 69.1%, p=0.55). Average-risk patients had significantly lower ALT levels (p=0.04) but had similar response to treatment as the high-risk individuals (sustained viral response 63.2 % versus 61%, p=0.87). Conclusion: Screening detects hepatitis C with lesser fibrosis but does not result in better response to pegylated interferon and ribavirin as compared with non-screened patients.
Keywords:
Screening
hepatitis C
fibrosis
treatment
Qatar
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