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SECTM1 Regulates Monocyte Levels and Is Associated With Incident Coronary Heart Disease
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DOI：10.1016/j.jacbts.2025.101378.png)
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Abstract
En 中文
• Proteomic profiling in large epidemiologic cohorts identified SECTM1 as a novel protein associated with incident CHD. • A variant associated with plasma levels of SECTM1 is associated with circulating monocyte percentage of WBC in large-scale genetic databases. • In vivo functional studies helped characterize SECTM1 as a novel regulator of circulating monocytes. • Further studies are needed to assess whether targeting SECTM1 can help prevent development of atherosclerosis.
Keywords:
coronary heart disease
genomics
inflammation
monocytes
omics
proteomics
CHD
coronary heart disease
cis-pQTL
cis-protein quantitative trait loci
GWAS
genome-wide association studies
IP
intraperitoneal
PBS
phosphate buffered saline
SNV
single-nucleotide variation (formerly SNP)
WBC
white blood cells
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