.png){kind=icon}
Return
Selenium and thyroid
.png){kind=icon}
PRE
AI
DOI：10.1016/j.beem.2009.08.002.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Inadequate supply of the essential trace element selenium (Se) has been associated with predisposition for, or manifestation of. various human diseases such as Keshan and Kashin-Beck disease, cancer, impaired immune function, neurodegenerative and age-related disorders and disturbances of the thyroid hormone axis. Se deficiency in combination with inadequate iodine contributes to the pathogenesis of myxedematous cretinism. rile recent identification Of various distinct selenocysteine-containing proteins, encoded by 25 human genes, provides information oil the molecular and biochemical basis of beneficial and possible adverse effects of this trace element The thyroid gland is among the human tissues with the highest Se content per mass unit similar to other endocrine organs and the brain Selenoproteins involved in cellular antioxidative defence systems and redox Control, Such as the glutathione peroxidase (GPx) and the thioredoxin reductase (TxnRd) family, are involved in protection of the thyroid gland from excess hydrogen peroxide and reactive oxygen species produced by the follicles for biosynthesis of thyroid hormones In addition, the three key enzymes involved in activation and inactivation of thyroid hormones. the iodothyronine deiodinases (DIO1,2,3), are selenoproteins with development, cell- and pathology-related expression patterns While nutritional Se supply is normally sufficient for adequate expression of functional Dio enzymes with exception of long-term parenteral nutrition and certain diseases impairing gastrointestinal absorption of Se compounds. the nutritional Se Supply for the protection of the thyroid gland and synthesis of some more abundant selenoproteins of the GPx and the TrxR family might be limiting their proper expression Under (patho-)physiological conditions (C) 2009 Elsevier Ltd. All rights reserved.
Keywords:
selenium
selenocysteine
selenomethionine
autoimmune thyroiditis
thyroid peroxidase antibody
thyroglobulin antibody
M Hashimoto
deiodinase
glutathione peroxidase
thioredoxin reductase
clinical trial
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
B
IF:
6.1
Papers:
1.7K
Citations:
5.5K
Organization
Cited Papers
Activation of transcriptionally active nuclear factor-KB by tumor necrosis factor-α and its inhibition by antioxidants in rat thyroid FRTL-5 cells.png)
ENDOCRINOLOGY
OAAI
ENDOCRINOLOGYIF3.3
OAAIShareSaveShareSaveShareSave
Effects of iodine repletion on thyroid morphology in iodine and or selenium deficient rat term fetuses, pups and mothersBIOCHIMIE
BIOCHIMIEIF3
PREAI
ShareSaveSelenium-mediated inhibition of transcription factor NF-kappa B and HIV-1 LTR promoter activity
PREAI
ShareSaveShareSave
View more