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Self-assembled DNA nanodevices for intelligent biosensing
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DOI：10.1039/D5NH00446B.png)
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Abstract
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Leveraging sequence specificity; shape programmability; and spatial addressability; DNA nanotechnology enables the nanometer-precise construction of DNA nanodevices for a wide range of biological applications. This minireview summarizes recent progress in employing self-assembled DNA nanostructures as scaffolds for creating advanced nanodevices as biosensors. We highlight notable advancements in ultrasensitive detection; multiplexed sensing; and targeted molecular bioimaging. These self-assembled DNA nanodevices are designed for intelligent sensing of various analytes; offering innovative solutions for biomedical diagnostics and environmental surveillance. Challenges related to the detection precision; stability; and scalable production of these promising DNA-based biosensors are also discussed.
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