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Self-assembling peptides construct supramolecular materials
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DOI：10.1039/D5CC06446E.png)
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Abstract
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Programmable peptide self-assembly enables the precise construction of supramolecular materials; establishing it as a defining frontier in nanomaterials research. This review systematically explores the collective contribution of sequence design; secondary structure regulation (including α-helices; β-sheets; and cyclic conformations); and dynamic modulation; and hierarchical organization in facilitating the creation of well-defined nanostructures such as nanotubes; nanopores; and nanocages. Artificial intelligence and computational modeling have emerged as critical tools to guide peptide design and predict assembly pathways; thereby enabling a strategic shift from empirical screening to mechanism-driven design. The review further highlights nanopore-based detection applications; demonstrating the potential for highly accurate; biocompatible detection of ions; nucleic acids; and proteins at single-molecule resolution. By integrating molecular design with biological function; this “from sequence-design to ordered structures to advanced applications” paradigm establishes a foundational framework for the development of precisely constructed functional supramolecular materials.
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