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Self-directed assembly drives spatial confinement polymerization for controlled capsule engineering
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DOI：10.1016/j.nantod.2024.102405.png)
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Abstract
En 中文
Facile and template-free synthesis of polyphenol-based polymer capsules is highly desired but remains challenging, owing to rapid oxidization of polyphenols and the corresponding uncontrolled assembly. Here, inspired by the natural structure and spontaneous assembly of cell membrane, we for the first time report a one-pot spatial confinement polymerization strategy based on the self-directed assembly of the smart lipid-like phenylboronate-dopamine derivatives (pDA). Both the experimental results and theoretical calculations demonstrate that these amphiphilic pDA molecules can spontaneously assemble into metastable vesicles, providing a spatially confined pre-capsules framework for the later cross-linking polymerization. Strikingly, the ingeniously designed hydrophobic phenylboronate ends not only block the catechol groups from rapid oxidization, but also take off / dissociate / decompose under the polymerization trigger-H2O2, thus enabling a controllable stimuli-responsive polymerization. Particularly, the uniform macroporous cavities with tunable sizes and sufficient cross-linking degree account for acoustic cavitation enhancement, providing a biocompatible sonosensitizer-free therapy platform. The general strategy paves the way toward the template-free synthesis of polyphenol-based capsules and may enlighten chemists to achieve intracellular synthesis of hollow polydopamine.
Keywords:
Self -assembly
Dopamine derivatives
Spatial confinement polymerization
Polydopamine capsules
Acoustic cavitation