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Self-documenting plasmids
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DOI：10.1016/j.tibtech.2025.03.010.png)
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Abstract
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Certificates with digital signatures embed identifying information and documentation into plasmid sequences to make them self-documenting. Certificates of 260 base pairs contain references to online documentation, and larger features can embed documentation files, such as gene annotations or data files, directly into the plasmid sequence. Plasmid variants are serialized with unique identification numbers so that customized documents can be directly associated with instances of individual plasmids. Self-documenting certified plasmid sequences are verified and their documentation retrieved from de novo sequence assemblies. Plasmid certification and embedding documentation does not impede expression in either bacterial or mammalian cells.
Keywords:
plasmid
digital signature
reproducibility
cyberbiosecurity
bioinformatics
sequencing
cryptography
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14.9
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NUCLEIC ACIDS RESEARCH
OAAI
NUCLEIC ACIDS RESEARCHIF13.1
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