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Semantic design: Programming functional genes from genomic context
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DOI：10.1016/j.xgen.2025.101132.png)
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Abstract
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Generative genomic models hold immense potential for creating intricate biological systems, yet designing precise functional sequences remains challenging. Merchant et al. in Nature present semantic design, which employs the Evo genomic language model to generate novel functional genes based solely on genomic context. Moreover, SynGenome database houses over 120 billion sequences generated through semantic design, spanning a diverse range of functions.
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