Senescent repair memory in chronic disease: Failed resolution as a driver of persistent organ dysfunction

doi:10.1016/j.arr.2026.103321

Senescent repair memory in chronic disease: Failed resolution as a driver of persistent organ dysfunction

2026-08-21

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DOI：10.1016/j.arr.2026.103321

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Abstract

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• Senescent repair memory reframes chronic disease as failed tissue resolution. • Metabolic, immune, epigenetic and spatial axes stabilize senescence. • Disease-specific senescent niches link repair failure to organ dysfunction. • Repair-resolution medicine offers a stage-aware approach to senotherapy.

Senescent repair memory in chronic disease: Failed resolution as a driver of persistent organ dysfunction

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