.png){kind=icon}
.png){kind=icon}
Return
Senolytics ameliorate cognitive decline in D-galactose-induced aging mice by inhibiting astrocytic cholesterol accumulation
.png){kind=icon}
PRE
AI
L
W
C
Z
K
杨
H
DOI：10.1016/j.mad.2026.112209.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• Senolytic (D+Q) treatment alleviates cognitive decline and cellular senescence in the aging mouse brain. • Multi-omics reveals senolytics specifically downregulate the hippocampal cholesterol biosynthesis pathway. • The anti-aging effects of senolytics are localized to a reduction in lipid droplets within astrocytes. • Inhibiting astrocytic cholesterol synthesis is both necessary and sufficient for senolytic efficacy. • Genetic overexpression of HSD17b7 reverses the benefits of senolytics, establishing a causal mechanism.
Keywords:
Cellular Senescence
Senolytics
Cognitive Decline
Cholesterol Metabolism
Astrocytes
Journal
IF:
5.1
Papers:
3.2K
Citations:
7.8K
Organization
Cited Papers