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SenSpots: when B cells age in place

delete2026-08-01
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PRE
AI
Q
Qianzhao Ji
刘光辉 cover
刘光辉 (Guang‐Hui Liu) *
J
Jing Qu *
DOI：10.1016/j.it.2026.07.008delete
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Abstract

Abstract

En 中文
Spatial multi-omics of aging human lymph nodes by Fan and colleagues reveals that immunosenescence manifests as focal B cell coalescence into ‘SenSpots’ within germinal centers, where concerted epigenetic, transcriptional, proteomic, and metabolic reprogramming spatially orchestrates the decline of humoral immunity.

Journal

Trends in Immunology cover
Trends in Immunology
IF:
13.9
Papers:
2.6K
Citations:
1.7W

Organization

C
chinese academy of sciences
Scholars:
54.9W
Papers: 44.5W
Citations: 703
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