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SESN2 Drives Osteoarthritis Progression by Inducing MFN2-Dependent Mitochondrial Hyperfusion in Rats

delete2026-06-01
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OA
AI
Y
Yiwen Zhang
Z
Zehang Zheng
W
Wenjie Hou
C
Chunran Pan
K
Kai Sun
J
Jiyun Li
X
Xiaofeng Deng
X
Xingru Shang
J
Jiawei Liu
R
Ruimin Chi
X
Xiaoxia Hao
F
Fengjing Guo
T
Tao Xu *
DOI:10.1016/j.joca.2026.05.014delete
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Abstract

Abstract

En 中文
This study aimed to elucidate the role of SESN2 in the pathological process of osteoarthritis (OA), with a particular focus on its potential mechanism in regulating chondrocyte mitochondrial function.
Keywords:
Mitochondrial hyperfusion
Post-traumatic OA
Chondrocyte
SESN2
MFN2
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Journal

Osteoarthritis and Cartilage cover
Osteoarthritis and Cartilage
IF:
9
Papers:
1.3W
Citations:
2.2W

Organization

H
huazhong university of science and technology
Scholars:
2.3W
Papers: 7.2K
Citations: 5
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