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Sex-dependent endocrine, cardiovascular, nociceptive and behavioral responses in rats cohabitating with a conspecific in chronic neuropathic pain
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DOI：10.1016/j.pnpbp.2026.111716.png)
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Abstract
En 中文
• Cohabiting with a partner in pain trigged hypernociception in both sexes. • Both sexes also shown anxiety-like behavior after cohabitation. • Pain exposure heightened stress-induced corticosterone, especially in females. • Baseline blood pressure rises in both sexes; heart rate rises only in females. • Females display blunted stress-evoked heart rate increase.
Keywords:
Anxiety
Emotional contagion
Glucocorticoids
Hypernociception
Hypertension
Psychosocial stress
BW
body weight
CCI
chronic constriction injury
CA
EPM closed arms
EPM
elevated plus maze test
HR
heart rate
MAP
mean arterial pressure
OA
EPM open arms
OF
open field test
PND
post-natal day
PWT
paw withdrawal threshold
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