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SGK1 downregulation co-occurs with leukocyte oligomeric α-synuclein accumulation in Parkinson’s disease
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DOI：10.1016/j.parkreldis.2025.108155.png)
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Abstract
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• SGK1 is regulator of cytoprotective response and immune activity • PD PBMCs exhibit low SGK1 and high oligomeric α-synuclein levels • PBMC SGK1 level discriminates PD from controls with robust AUC performance • SGK1 levels were reduced even in PD serum • In PD SGK1 is globally downregulated emerging as a potential disease target
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