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Shikimic acid ameliorates immobilization-induced muscle atrophy through regulation of inflammation and muscle protein homeostasis
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DOI：10.1016/j.jnutbio.2026.110434.png)
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Abstract
En 中文
• Shikimic acid mitigates immobilization-induced skeletal muscle atrophy in mice. • Shikimic acid attenuates muscle atrophy via the PI3K/Akt/mTOR signaling pathway. • Shikimic acid suppresses NF-κB–mediated inflammatory signaling. • Shikimic acid ameliorates muscle mass loss and myofiber CSA in immobilized mice. • Shikimic acid prevents declines in grip strength and exercise capacity in mice.
Keywords:
Immobilization-induced muscle atrophy
Shikimic acid
Muscle protein turnover
NF-κB signaling
PI3K/Akt/mTOR pathway
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