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Shotgun Metagenomics Reveals Skin Microbiome Composition and Function in Infant Atopic Disease
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DOI：10.1111/all.70449.png)
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Abstract
En 中文
Atopic dermatitis (AD), food sensitization (FS), and food allergy (FA) frequently co-occur in infancy, but the factors underlying distinct atopic phenotypes remain unclear. Although FLG null mutations are major genetic risk factors for AD, they explain only part of disease heritability, suggesting a potential role for the skin microbiome. This study examined how early-life skin microbiome composition and its interaction with host genetics contribute to distinct atopic phenotypes in infancy.
Keywords:
atopic dermatitis
early life
FLG mutation
food allergy
host-microbiome interaction
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