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Shouhui Tongbian Capsule Is Associated with Antidepressant-Like Effects and Gut-Brain Axis-Related Biological Improvements in Mouse Models of Depression
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DOI：10.1016/j.brainresbull.2026.111931.png)
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Abstract
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• SHTB attenuates LPS-induced depressive and anxiety-like behaviors in mice • SHTB reverses CUMS-induced depressive-like and anxiety-like behaviors in mice • SHTB alleviated LPS-induced neuroinflammation and neuronal loss in the hippocampus • SHTB rescues synaptic loss in LPS-induced depressive mice • SHTB ameliorates gut barrier dysfunction of colon tissue driven by LPS
Keywords:
Shouhui Tongbian Capsule
Depression
Gut-brain axis
Neuroinflammation
Synaptic plasticity
Network pharmacology
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