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Silencing PACS2 attenuates cardiac hypertrophy by inhibiting ferroptosis via activating SIRT1

delete2026-05-14
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PRE
AI
Z
Zhijie Shen
Y
Yinzhuang Zhang
L
Li Fang *
DOI：10.1016/j.yjmcc.2026.05.007delete
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Abstract

Abstract

En 中文
• PACS2 silencing inhibits Ang-II-triggered hypertrophy in cardiomyocytes. • PACS2 silencing promotes SIRT1 expression and activates Nrf2/HO-1 pathway. • PACS2 silencing improves cardiac hypertrophy by promoting SIRT1 expression. • HIC1 is a transcription regulatory factor of SIRT1. • PACS2 affects SIRT1 expression by binding to HIC1.
Keywords:
PACS2
SIRT1
cardiac hypertrophy
ferroptosis
HIC1

Journal

Journal of Molecular and Cellular Cardiology cover
Journal of Molecular and Cellular Cardiology
IF:
4.7
Papers:
9.9K
Citations:
1.4W

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