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Silibinin restricts mitochondria-associated inflammatory pathways in LPS-stimulated murine microglia BV2 through TREM2

delete2026-04-06
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PRE
AI
W
Wenhui Chen
X
Xiaoling Wang
P
Panwen Liu
Y
Yu Kang
T
Toshihiko Hayashi
K
Kazunori Mizuno
S
Shunji Hattori
H
Hitomi Fujisaki
W
Weiwei Liu *
T
Takashi Ikejima *
DOI：10.1016/j.cellimm.2026.105102delete
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Abstract

Abstract

En 中文
• Silibinin suppresses LPS-activated pro-inflammatory pathways in BV2 microglia. • Silibinin inhibits mitochondrial disorders and downstream STING/NLRP3 activation. • Downregulating TREM2 causes mitochondrial disorders and induces inflammation. • Silibinin stabilizes TREM2, mitigating mitochondrial stress in LPS-treated BV2 cells.
Keywords:
Silibinin
TREM2
mitochondrial disorders
NLRP3
STING

Journal

Cellular Immunology cover
Cellular Immunology
IF:
2.9
Papers:
3.6K
Citations:
6.1K

Organization

N
nippi research institute of biomatrix
Scholars:
3
Papers: 1
Citations: 0
S
Shenyang Pharmaceutical University
Scholars:
1.3W
Papers: 6.2K
Citations: 7.9K
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