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Simultaneous multislice acquisition without trajectory modification for hyperpolarized 13C experiments
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DOI：10.1002/mrm.27136.png)
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Abstract
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Purpose: To investigate the feasibility of performing large FOV hyperpolarized C-13 metabolic imaging using simultaneous multislice excitation. Methods: A spectral-spatial multislice excitation pulse was constructed by cosine modulation and incorporated into a C-13 spiral imaging sequence. Phantom and in vivo pig experiments were performed to test the feasibility of simultaneous multislice data acquisition and image reconstruction. In vivo cardiac-gated images of hyperpolarized pyruvate, bicarbonate, and lactate were obtained at 1 x 1 x 1 cm(3) resolution over a 48 x 48 x 24 cm(3) FOV with 2-fold acceleration in the slice direction. Sensitivity encoding was used for image reconstruction with both autocalibrated and numerically calculated coil sensitivities. Results: Simultaneous multislice images obtained with 2-fold acceleration were comparable to reference unaccelerated images. Retained SNR figures greater than 80% were achieved over the part of the image containing the heart. Conclusion: This method is anticipated to enable large FOV imaging studies using hyperpolarized C-13 substrates, with an aim toward whole-body exams that have to date been out of reach.
Keywords:
C-13
hyperpolarization
parallel imaging
simultaneous multislice
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ShareSaveShareSaveHyperpolarized 13C Metabolic MRI of the Human Heart Initial Experience.png)
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