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Single-cell profiling unveils an exhaustion trajectory of ZNF683hi tissue-resident alveolar CD8+ T cells in checkpoint inhibitor pneumonitis
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DOI：10.1016/j.medj.2026.101180.png)
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Abstract
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• CIP is driven by tissue-resident ZNF683hi CD8+ exhausted T cells • RP arises from peripherally derived GZMKhi CD8+ T cells • Divergent T cell origins define mechanistic differences between pneumonitis types • These insights guide differential diagnosis and ICI rechallenge decisions
Keywords:
checkpoint inhibitor pneumonitis
ZNF683
tissue-resident CD8+ T cells
ICI rechallenge
radiation pneumonitis
differential diagnosis
translation to patients
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