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Single-cell RNA-seq reveals a persistent interferon signature in immune cells from systemic lupus erythematosus patients with high versus low polygenic risk scores despite antimalarial treatment
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DOI：10.1016/j.jaut.2026.103575.png)
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Abstract
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• Single-cell analysis shows High-PRS patients have elevated IFN across immune cells. • Low-PRS SLE patients on antimalarials show IFN activity like healthy controls. • Antimalarial therapy alone may not suppress subclinical IFN in high-risk patients. • Genetic risk scoring can guide precision therapy to target immune dysregulation.
Keywords:
interferon signature
polygenic risk scores
single-cell RNA-seq
systemic lupus erythematosus
antimalarial therapy
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