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Single-cell RNA sequencing identifies long non-coding RNAs enriched in psoriatic epidermal subsets
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DOI：10.1016/j.jdermsci.2026.03.002.png)
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Abstract
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• Single-cell atlas reveals lncRNA profiles in healthy and psoriatic epidermis • 1412 lncRNAs show keratinocyte- or immune cell-specific enrichment • LINC01137 is IL-17A–inducible and enriched in activated keratinocytes • LINC00892 marks Th1, Th17, and cytotoxic T cells in psoriatic lesions • lncRNAs may serve as biomarkers or therapeutic targets in psoriasis
Keywords:
Psoriasis
single-cell RNA sequencing
long non-coding RNA
keratinocyte
LINC01137
LINC0892
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