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Single, early intravesical instillation of pirarubicin in the prevention of bladder recurrence after radical nephroureterectomy for upper tract urothelial carcinoma (JCOG1403): a multicentre, open-label, randomised, phase 3 trial

delete2026-07-11
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PRE
AI
A
Akihiro Ito *
Y
Yoichi Arai
Y
Yoshiyuki Kakehi
M
Masayuki Yokoyama
K
Keita Sasaki
M
Motohide Uemura
A
Atsushi Takahashi
K
Kazuo Nishimura
T
Takashi Kawahara
H
Hitoshi Masuda
K
Koji Yoshimura
T
Takashi Kobayashi
M
Masatoshi Eto
T
Tsukasa Igawa
N
Naotaka Nishiyama
T
Takanori Mochizuki
A
Akira Yokomizo
M
Makito Miyake
T
Tomohiko Ichikawa
K
Katsuyoshi Hashine
DOI:10.1016/S1470-2045(26)00130-0delete
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Abstract

Abstract

En 中文
A previous phase 2 trial of single, postoperative intravesical instillation of pirarubicin after radical nephroureterectomy for upper tract urothelial carcinoma showed promising results in reducing the risk of bladder recurrence. We aimed to further evaluate the efficacy and adverse events of pirarubicin in this setting compared with the standard-of-care treatment of no intravesical instillation.

Journal

T
The Lancet Oncology
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Papers:
348
Citations:
1

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