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Single Pulse Nanosecond Laser-Stimulated Targeted Delivery of Anti-Cancer Drugs from Hybrid Lipid Nanoparticles Containing 5 nm Gold Nanoparticles
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DOI：10.1002/smll.202305591.png)
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Abstract
En 中文
Encapsulating chemotherapeutic drugs like doxorubicin (DOX) inside lipid nanoparticles (LNPs) can overcome their acute, systematic toxicity. However, a precise drug release at the tumor microenvironment for improving the maximum tolerated dose and reducing side effects has yet to be well-established by implementing a safe stimuli-responsive strategy. This study proposes an integrated nanoscale perforation to trigger DOX release from hybrid plasmonic multilamellar LNPs composed of 5 nm gold (Au) NPs clustered at the internal lamellae interfaces. To promote site-specific DOX release, a single pulse irradiation strategy is developed by taking advantage of the resonant interaction between nanosecond pulsed laser radiation (527 nm) and the plasmon mode of the hybrid nanocarriers. This approach enlarges the amount of DOX in the target cells up to 11-fold compared to conventional DOX-loaded LNPs, leading to significant cancer cell death. The simulation of the pulsed laser interactions of the hybrid nanocarriers suggests a release mechanism mediated by either explosive vaporization of thin water layers adjacent to AuNP clusters or thermo-mechanical decomposition of overheated lipid layers. This simulation indicates an intact DOX integrity following irradiation since the temperature distribution is highly localized around AuNP clusters and highlights a controlled light-triggered drug delivery system. Laser-triggered release of anticancer doxorubicin from gold nanoparticle-containing liposomes is reported using a pulsed nanosecond laser to promote a site-specific drug release, thereby avoiding side effects. The numerical simulations demonstrate that single pulse interaction with gold nanoparticles residing within a liposome leads to nanoscale thermal decomposition of the surrounding lamellae, allowing the rapid release of the encapsulated drug.image
Keywords:
lipid nanoparticles
nanosecond pulsed laser
plasmonic gold nanoparticles
single pulse perforation
stimulus-responsive drug release
targeted drug delivery
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