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Single-site amino acid residue mutation reshapes the characteristics of double bond positions for protostadienol-type triterpenols
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DOI：10.1016/j.phytochem.2026.114950.png)
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Abstract
En 中文
• Single F726N mutation in plant AoCAS produces fungal-specific Δ17(20)-protostadienol, overcoming natural biosynthetic barriers. • N726 acts as a general base mediating dual deprotonation, clarifying dual protostadienol isomer formation mechanism. • F→N mutation in diverse C-B-C OSCs (AjPS/SgCBQ) realizes same functional switch, confirming cross-species universality. • This work lays a foundation for precise triterpenoid biosynthesis and efficient pharmaceutical precursor preparation.
Keywords:
AoCAS
F726N mutation
protostadienol
triterpenoid biosynthesis
double bond positions
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3.4
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1.3W
Citations:
3.2W
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