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Sizing up metatranscriptomics
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DOI：10.1038/ismej.2012.94.png)
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Abstract
En 中文
A typical marine bacterial cell in coastal seawater contains only similar to 200 molecules of mRNA, each of which lasts only a few minutes before being degraded. Such a surprisingly small and dynamic cellular mRNA reservoir has important implications for understanding the bacterium's responses to environmental signals, as well as for our ability to measure those responses. In this perspective, we review the available data on transcript dynamics in environmental bacteria, and then consider the consequences of a small and transient mRNA inventory for functional metagenomic studies of microbial communities.
Keywords:
mRNA
metatranscriptomics
macromolecules
bacteria
Journal
IF:
10
Papers:
4.3K
Citations:
4.2W