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Skeletal muscle reprogramming of metabolic, ribosomal and developmental pathways contributes to Roux-en-Y gastric bypass-induced adaptation in women
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DOI：10.1016/j.ebiom.2026.106410.png)
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Abstract
En 中文
Understanding how skeletal muscle responds to weight loss is crucial for developing targeted strategies to manage obesity and promote sustained improvement in metabolic health. Here, we investigated the molecular mechanisms underlying skeletal muscle reprogramming of gene expression and metabolic activity following Roux-en-Y gastric bypass (RYGB).
Keywords:
Obesity
Weight loss
Type 2 diabetes
Epigenetics
DNA methylation
Transcriptomics
Metabolism
Bariatric surgery
Mitochondria
Ribosome
4E-BP1
4E-binding protein 1
ACACB
acetyl-CoA carboxylase beta
ADIPOQ
adiponectin
ALDH1L2
aldehyde dehydrogenase 1 family member L2
ALDH5A1
aldehyde dehydrogenase 5 family member A1
ATF5
activating transcription factor 5
ATP2A1
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1
BIA
bioimpedance analysis
BOK
BCL2 family apoptosis regulator
BPD/DS
biliopancreatic diversion with duodenal switch
CAMLG
calcium modulating ligand
CDKN1C
cyclin dependent kinase inhibitor 1C
CI
complex I
COX17
cytochrome c oxidase copper chaperone COX17
CS
citrate synthase
DAG
diacylglycerol
DGAT2
diacylglycerol O-acyltransferase 2
DMP
differentially methylated CpG position
DMR
differentially methylated gene regions
EHMT2
euchromatic histone lysine methyltransferase 2
eIF
eukaryotic initiation factor
ESRRG
oestrogen related receptor γ
ETC
electron transport chain
FABP4
fatty acid binding protein 4
FFM
fat-free mass
FTL
ferritin light chain
GDNF
glial cell derived neurotrophic factor
GLP1
glucagon-like peptide-1
IMTG
intramuscular triglyceride
JAK2
Janus kinase 2
LEP
leptin
MMP2
matrix metalloproteinase-2
MSTN
myostatin
MYOM2
myomesin 2
MYO1C
Myosin IC
OXPHOS
oxidative phosphorylation
PAX6
paired box 6
PDK4
pyruvate dehydrogenase kinase 4
PDLIM7
PDZ and LIM domain 7
PIC
pre-initiation complex
PITX1
paired-like homeodomain transcription factor 1
PPARGC1A/PGC1α
PPARG coactivator 1 α
PLIN1
perilipin 1
PTPRE
protein tyrosine phosphatase receptor type E
PTRF/Cavin-1
polymerase I and transcript release factor
PWL
percentage weight loss
RBFA
ribosome binding factor A
REXO2
RNA exonuclease 2
RNA-seq
RNA sequencing
RYGB
Roux-en-Y gastric bypass
S100A1
S100 calcium binding protein A1
SELENOW
selenoprotein W
SERPINE2
serpin family E member 2
SL-1
selectivity factor 1
SLC16A3
monocarboxylate transporter 4/solute carrier family 16 member 3
SLC25A5
adenine nucleotide translocase 2/solute carrier family 25 member 5
SLC40A1
Ferroportin-1/solute carrier family 40 member 1
SMAD4
SMAD family member 4
SOX6
SRY-box transcription factor 6
T2D
type 2 diabetes
TBP
TATA-binding protein
TIF-IA
transcription initiation factor IA
TF
Transferrin
TNF
tumour necrosis factor α
TOPBP1
DNA topoisomerase II binding protein 1
TP53
tumour protein p53
TPM1
tropomyosin 1
UBF
upstream binding factor
UCP3
uncoupling protein 3
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