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Skin toxicity of liquid crystal monomers (LCMs): Mitochondrial dysfunction and metabolic dysregulation revealed by integrated multi-omics analysis
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DOI：10.1016/j.ecoenv.2026.119953.png)
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Abstract
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• In vitro experiments revealed that LCMs exposure impaired mitochondrial function in HaCaT cells in a time-dependent manner. • Activation of the TNF signaling pathway, along with significant downregulation of PLOD2, DNA damage-inducible DDIT4, and CE proteins. • Disruptions in the TCA cycle, glutathione metabolism, and purine metabolism, with downregulation of key metabolites. • β-alanylleucine was identified as a potential metabolic biomarker for LCMs-induced skin injury.
Keywords:
Liquid crystal monomers
Skin damage
Metabolic disruption
Multi-omics analysis
β-alanylleucine
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