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Smart molecularly imprinted 2D photonic organohydrogel enabled by mixed-solvent polymerization for selective sensing of low-solubility hydrocortisone
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PRE
AI
M
H
L
J
张
W
DOI：10.1016/j.mtchem.2026.103628.png)
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Abstract
En 中文
Hydrocortisone (HC) is a crucial glucocorticoid requiring regular monitoring due to its vital physiological roles and the health risks. While various sensitive detection methods exist, they often rely on sophisticated instruments and complex procedures, limiting their practical application. Therefore, developing a portable and straightforward detection method with high selectivity remains an urgent need. Herein, we report a smart molecularly imprinted two-dimensional photonic organohydrogel sensor, fabricated via mixed-solvent polymerization, capable of selective and sensitive detection of poorly water-soluble HC. The sensor was fabricated via UVinitiated polymerization of acrylamide and acrylic acid in an ethanol-water mixed solvent, using HC as the template molecule. After template removal, nanocavities complementary to HC in shape, size, and binding sites were formed within the organohydrogel containing two-dimensional photonic crystal (2DPC) based on polystyrene microspheres. Upon exposure to HC, specific rebinding through hydrogen bonding induced HC molecules to enter the nanocavities, increasing the osmotic pressure inside gel, and enabling the organohydrogel sensor swelling. This increased the particle spacing of the 2DPC and resulted in a measurable shift in the Debye diffraction ring. The sensor exhibited a linear response across HC concentration ranges of 100 nM-0.1 mM, 0.1-1.0 mM, and 1.0-11.0 mM, with a limit of detection of 53.4 nM. The sensor demonstrated robust regeneration capability, allowing for multiple detection cycles without significant performance degradation. It was successfully applied to determine HC in injection samples. This work demonstrates a novel strategy for detecting low-water-solubility analytes by employing a mixed-solvent system to prepare organohydrogel-based photonic sensors, thereby broadening the applicability of 2DPC sensors for use under demanding conditions.
Keywords:
Two-dimensional photonic crystal
Organohydrogel sensor
Molecular imprinting
Low water-solubility
Hydrocortisone detection
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