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SMD2 reads pseudouridines to regulate mRNA splicing and promote tumorigenesis
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DOI：10.1016/j.molcel.2026.06.033.png)
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Abstract
En 中文
• SMD2 preferentially binds ψ in mRNA and functions as a ψ reader • ψ depletion or SMD2 loss induces widespread alternative splicing changes • SMD2 recognizes ψ-modified transcripts to regulate mRNA splicing • The ψ-SMD2 axis represents a potential therapeutic vulnerability in cancer
Journal
IF:
16.6
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1.0W
Citations:
8.5W
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Cited Papers