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Social dysfunction and default mode network functional integrity in neuropsychiatric disorders: A cross-disorder replication and generalization study
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DOI：10.1016/j.euroneuro.2026.112847.png)
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Abstract
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• This study was specifically designed to replicate and generalize findings from the PRISM1 project. • A link between reduced default mode network (DMN) intrinsic functional connectivity and social dysfunction across schizophrenia, Alzheimer’s disease, and healthy control participants was replicated. • This association extended to major depressive disorder patients. • Relations between DMN activation in response to emotional face stimuli and social dysfunction were not replicated. • Altered DMN functional connectivity is a cross-disorder treatment target for social dysfunction.
Keywords:
Social dysfunction
Resting-state
Facial emotional processing
Schizophrenia
Major depressive disorder
Alzheimer’s disease
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