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    Sodium-Glucose Cotransporter 2 Inhibitors Decrease Contrast Induced Nephropathy In Patients With Heart Failure With Reduced Ejection Fraction Without Diabetes Mellitus

    10.1007/s44411-025-00358-4
    2025-09-01
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    Abstract

    Abstract

    En 中文
    Purpose The aim of our study was to investigate the effect of sodium-glucose cotransporter 2 inhibitors (SGLT2i) treatment on the development of contrast induced nephropathy (CIN) in patients with heart failure with reduced ejection fraction (HFrEF) without diabetes mellitus (DM) undergoing elective coronary angiography (CAG) and percutaneous coronary intervention (PCI). Methods In this retrospective study after exclusion criteria, 390 patients (242 men, 148 women, mean age 63.7 +/- 8.6 years) were included. Patients were divided into two groups as with and without CIN and all parameters were compared and the parameters determining the patient group with CIN were found. Results CIN occurred in 76 (19.5%) of 390 patients. Age (p = < 0.001), smoking (p = 0.015), total procedure time (p = 0.018), contrast volume (p = < 0.001) and PCI (p = 0.030) were significantly higher and left ventricular ejection fraction (LVEF) (p = < 0.001) and SGLT2i use were lower (p = 001) in the CIN group. In the logistic regression analysis, it was found that advanced age (OR = 1.215, %95CI-1.144-1.290, p < 0.001), low LVEF (OR = 0.858, %95 CI-0.807-0.912, p < 0.001), increased contrast volume (OR = 1.030, %95 CI-1.016-1.044, p < 0.001) and not using SGLT2i treatment (OR = 0.269, %95 CI-0.163-0.454, p < 0.001) were found to independently determine the risk of CIN. Conclusion In conclusion, SGLT2i treatment significantly reduced the development of CIN in HFrEF patients without DM. Our findings need to be supported by multicenter prospective randomized controlled trials.
    Keywords:
    Oronary angiography
    Contrast-induced nephropathy
    Sodium-glucose cotransporter 2 inhibitors
    Heart failure
    Journal

    Journal

    B
    BRATISLAVA MEDICAL JOURNAL
    IF:
    1.1
    Papers: 203
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    Citations: 0
    Researchers

    Researchers

    K
    Koca, Fadime
    H-index:
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    Papers: 1
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    A
    Ardic, Mustafa Lutfullah
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    Papers: 1
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    Citations: 0
    H
    Harbalioglu, Hazar
    H-index:
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    Papers: 1
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    Citations: 0
    C
    Cetin, Abdullah Eren
    H-index:
    0
    Papers: 1
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    Citations: 0
    K
    Kaya, Bercem Berent
    H-index:
    0
    Papers: 1
    ・
    Citations: 0
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