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Solid-state NMR spectroscopy in pharmaceutical sciences
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DOI：10.1016/j.trac.2020.116152.png)
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Abstract
En 中文
Solid-state NMR (ssNMR) spectroscopy analyzes a wide range of pharmaceutical materials in a nondisruptive and non-invasive manner. The obtained molecular properties at macroscopic and microscopic scales offer critical knowledge on the physiochemical stability of drug substances and drug products. ssNMR is well suited to characterize multicomponent solids, providing insight into the formulation process and composition, as well as investigating structural attributes for drug delivery. Compared to other solid-state analysis techniques, ssNMR offers unique and comprehensive perspectives for its inherently quantitative nature, high sensitivity to differentiate individual chemicals, the atomic resolution to elucidate local structures and intricate interactions, the capability to probe molecular packings of amorphous materials, and its ability to study molecular motions at different timescales. This review will introduce the advancement and application of ssNMR in pharmaceutical sciences to overcome challenges in material characterizations. We aim to include examples of molecular investigation on primary structural behaviors and physicochemical attributes of drug substances, excipients and solid dosages. (C) 2020 The Author(s). Published by Elsevier B.V.
Keywords:
Solid-state NMR
Fast magic angle spinning
Dynamic nuclear polarization
Pharmaceutical analysis
Drug substance
Solid dosage
Quantification
Polymorphism
Miscibility and homogeneity
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