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SPACE-seq integrates spatial transcriptomics and lineage tracing in native tissues

delete2026-06-09
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PRE
AI
Y
Yuemeng Jia
D
Dawei Sun
J
Jackson A. Weir
X
Xugeng Liu
A
Andrew J.C. Russell
Y
YeEun Kim
N
Nicholas Thom
G
Giovanni Marrero
V
Vipin Kumar
F
Fei Chen *
F
Fernando D. Camargo *
DOI:10.1016/j.stem.2026.05.017delete
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Abstract

Abstract

En 中文
• SPACE-seq maps lineage, cell state, and tissue architecture in situ • Clonally related iCCA cells diversify into distinct tumor states • SPACE-seq identifies fate-shaping tumor-stroma crosstalk • Early hepatoblast dispersion defines spatial domains for liver lobe formation

Journal

Cell Stem Cell cover
Cell Stem Cell
IF:
20.4
Papers:
3.6K
Citations:
3.1W

Organization

H
Harvard University
Scholars:
26.2W
Papers: 21.9W
Citations: 28.7W
B
boston children’s hospital
Scholars:
80
Papers: 45
Citations: 0
B
Broad Institute of Harvard and MIT
Scholars:
233
Papers: 76
Citations: 25
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