.png){kind=icon}
.png){kind=icon}
Return
SPARC induction and correlation with inflammation and fibrosis in a mouse model of alkali-induced abdominal adhesions
.png){kind=icon}
OA
AI
H
D
S
DOI：10.1016/j.jphs.2026.06.006.png)
.png){kind=icon}
.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Postoperative abdominal adhesions can cause several complications, such as intestinal obstruction, female infertility, and chronic pelvic pain. By alkaline cauterization of the cecum, we established a mouse abdominal adhesion model to investigate the roles of secreted protein acidic and rich in cysteine (SPARC) in adhesion formation. Alkaline cauterization led to elevation of adhesion scores and mRNA levels of SPARC, monocyte chemoattractant protein-1 (MCP-1), tumor necrosis factor-α (TNF-α), and collagen I on Days 3, 7, and 14, with a positive correlation between SPARC levels and MCP-1, TNF-α, and collagen I during Days 3-14. Histological assessment revealed the presence of fibrillar collagen in the adhesive tissue between the cecum and other organs/tissues and SPARC at the fibrotic sites. Matrix metalloproteinase (MMP)-9 and MMP-2 were upregulated in the adhesion group on Days 3-7 and 7-14, respectively, with these expressions correlating with SPARC on Days 3, 7, and 14. A disintegrin and metalloproteinase with thrombospondin type 1 motif (ADAMTS1), which colocalized with SPARC, was increased in the adhesion model, and showed a positive correlation with SPARC, MCP-1, TNF-α, and collagen I on Days 3 and 7, but not on Day 14. In conclusion, SPARC induction might play important roles in adhesion formation and development.
Keywords:
Abdominal adhesion
Secreted protein acidic and rich in cysteine
Inflammation
Fibrosis
A disintegrin and metalloproteinase with thrombospondin type 1 motif
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
2.9
Papers:
3.3K
Citations:
4.7K
