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Sparse thalamocortical convergence
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DOI：10.1016/j.cub.2021.02.032.png)
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Abstract
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How many thalamic neurons converge onto a cortical cell? This is an important question, because the organization of thalamocortical projections can influence the cortical architecture.(1,2) Here, we estimate the degree of thalamocortical convergence in primary visual cortex by taking advantage of the cortical expansion-neurons within a restricted volume in primary visual cortex have overlapping receptive fields driven by a smaller set of inputs from the lateral geniculate nucleus.(3-5) Under these conditions, the measurements of cortical receptive fields in a population can be used to infer the receptive fields of their geniculate inputs and the weights of their projections using non-negative matrix factorization.(6) The analysis reveals sparse connectivity,(7) where a handful ((similar to)2-6) of thalamic inputs account for 90% of the total synaptic weight to a cortical neuron. Together with previous findings,(8) these results paint a picture consistent with the idea that convergence of a few inputs partly determine the retinotopy and tuning properties of cortical cells.(8-13)
Keywords:
ORIENTATION COLUMNS
RECEPTIVE-FIELDS
NEURONS
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