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Spatially resolved multi-omics reveals that paeoniflorin ameliorates IgA nephropathy via Oat, Aco1 and Fh-mediated metabolic reprogramming and tubuloimmune crosstalk
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DOI：10.1016/j.phymed.2026.158263.png)
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Abstract
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• Integrated spatial multi-omics reveals the region-specific mechanism of Paeoniflorin in IgA nephropathy. • Paeoniflorin targets the Oat, Aco1, and Fh axis for renal metabolic reprogramming. • Paeoniflorin induces cortical TCA cycle disruption and upregulates arginine metabolism. • Tubuloimmune crosstalk between DTCs and macrophages is reshaped by Paeoniflorin. • In vitro assays confirm Paeoniflorin's direct anti-inflammatory effects via Oat, Aco1, and Fh.
Keywords:
Paeoniflorin
IgA nephropathy
metabolic reprogramming
tubuloimmune crosstalk
spatial multi-omics
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8.3
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9.0K
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3.1W
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