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Specific reversal agents for direct oral anticoagulants in neurosurgical emergencies – a systematic review

delete2025-10-13
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OA
AI
L
Laura Zeller *
J
Jonas Rohr
G
Giorgio Brandi
C
Christoph Globas
A
Alexander Kaserer
M
Matthias Greutmann
T
Tilman Schubert
J
Jan–Dirk Studt
K
Katharina Geiling
L
Luca Regli
M
Menno R. Germans
DOI:10.1016/j.rpth.2025.103225delete
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Abstract

Abstract

En 中文
Direct oral anticoagulants (DOACs) are widely used but pose significant challenges in emergency neurosurgical settings. Idarucizumab and andexanet alfa are approved reversal agents, yet their effectiveness and safety in neurosurgical emergencies remain unclear. This systematic review evaluates the current evidence on DOAC reversal in patients undergoing emergency neurosurgical interventions.
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Journal

Research and Practice in Thrombosis and Haemostasis cover
Research and Practice in Thrombosis and Haemostasis
IF:
3.4
Papers:
1.9K
Citations:
3.3K

Organization

U
university of zurich
Scholars:
4.9W
Papers: 3.9W
Citations: 65
U
University Hospital Zurich and University of Zurich
Scholars:
95
Papers: 26
Citations: 0