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Spi-B and IRF1 activate tumor immunogenicity downstream of the Epstein-Barr virus protein LMP1
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DOI：10.1016/j.celrep.2026.117824.png)
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Abstract
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• LMP1 converts solid tumor cells into immunostimulatory cells • LMP1 promotes endogenous retrovirus-derived tumor antigen presentation • Spi-B and IRF1 upregulate expression of CD80 and MHC-I downstream of LMP1 • Spi-B and IRF1 induce CD8+ T cell responses and suppress tumor growth
Keywords:
Epstein-Barr virus
latent membrane protein 1
immune surveillance
tumor immunogenicity
endogenous retrovirus
Spi-B
IRF1
cancer immunotherapy
antigen presentation
CD8+ T cells
CP: immunology
CP: cancer
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