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Spindle errors: A stress test for epithelial robustness
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DOI：10.1016/j.tcb.2026.06.006.png)
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Abstract
En 中文
Bosveld et al. uncover how epithelial tissue buffers mitotic spindle errors. In the Drosophila notum, cells displaced by spindle misorientation either reintegrate via cell-autonomous and nonautonomous forces or are eliminated. This coordinated response links cell and tissue mechanics, Hippo-dependent survival signaling, and systemic tumor necrosis factor signaling-mediated apoptosis to maintain epithelial homeostasis.
Keywords:
epithelium
spindle orientation
tissue homeostasis
tissue mechanics
apoptosis
Drosophila
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