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Spirulina platensis and β-glucan mitigate cyclophosphamide-induced Immunosuppression in broilers: Differential effects of preventive and therapeutic strategies via redox–inflammatory modulation
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DOI：10.1016/j.psj.2026.107250.png)
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Abstract
En 中文
Immunosuppression remains a major constraint in intensive poultry production, compromising growth performance and increasing susceptibility to disease. This study investigated the comparative preventive and therapeutic efficacy of dietary Spirulina platensis and β-glucan in broiler chickens subjected to cyclophosphamide-induced immunosuppression. A total of 240 one-day-old Sasso broiler chicks were casually allotted into six experimental groups (n = 40/group; 4 replicates of 10 birds). Treatments included a control, a cyclophosphamide-treated group, and groups supplemented with Spirulina or β-glucan in either preventive or therapeutic regimens. Growth performance, lymphoid organ indices, hematological parameters, phagocytic activity, oxidative stress biomarkers, inflammatory gene expression, and histopathological alterations were evaluated on days 21 and 28.
Keywords:
Broiler
Immunosuppression
Spirulina platensis
β-glucan
Oxidative stress
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