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Splicing: HACking into the unfolded-protein response
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DOI：10.1016/S0960-9822(98)70986-8.png)
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Abstract
En 中文
Unfolded proteins in the endoplasmic reticulum of Saccharomyces cerevisiae trigger a specialized RNA splicing event that allows the subsequent translation of the Hac1p transcription factor. This splicing can be reconstituted with Ire1p, a transmembrane kinase that has a site-specific RNase activity, and tRNA ligase. (C) Current Biology Ltd.
Keywords:
TRANSFER-RNA LIGASE
KAR2 BIP GENE
ENDOPLASMIC-RETICULUM
TRANSMEMBRANE PROTEIN
KINASE
YEAST
OLIGOMERIZATION
PHOSPHORYLATION
INDUCTION
NUCLEUS
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