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Spontaneous association of different forms of non-conjugated astatine-211 to serum albumin
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DOI：10.1016/j.nucmedbio.2026.109608.png)
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Abstract
En 中文
Astatine-211 is one of the alpha-particle emitting nuclides investigated for use within Targeted Alpha Therapy (TAT) of disseminated cancer. In previous studies, a difference in blood clearance has been observed when comparing astatinated compounds with their iodinated counterparts. This has been explained by a potentially prolonged retention in the blood by present free astatine. This study examined the spontaneous binding of non-conjugated astatine to albumin under physiological conditions in vitro and compared it to that of iodine. Additionally, the in vivo blood circulation patterns of free astatine were assessed and contrasted with those of iodine.
Keywords:
Astatine-211
Albumin
Targeted alpha therapy
In vivo behavior
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