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Spontaneous cell polarization: undermining determinism

delete2003-04-01
delete112
PRE
AI
R
Roland Wedlich‐Söldner
R
Rong Li
DOI：10.1038/ncb0403-267delete
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Abstract

Abstract

En 中文
It is widely observed that eukaryotic cells can polarize spontaneously in the absence of pre-established asymmetric cues. This phenomenon indicates that the principle of self-organization may be central to the establishment of cell polarity. Modelling work, as well as recent experimental data from several organisms, suggests that a combination of local positive feedback loops and global inhibitors could result in robust cell symmetry breaking through amplification of minute, stochastic variations.
Keywords:
PELVETIA-COMPRESSA ZYGOTES
BUD-SITE SELECTION
CORTICAL ROTATION
SELF-ORGANIZATION
PATTERN-FORMATION
BUDDING YEAST
XENOPUS EGGS
POLARITY
CHEMOTAXIS
GROWTH
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Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.

Journal

Nature Cell Biology cover
Nature Cell Biology
IF:
19.1
Papers:
6.1K
Citations:
4.8W

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