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Sprayable supramolecular hydrogel with minimalism for wilderness first aid: integration of mechanical performance and biofunctionality
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DOI：10.1186/s42825-026-00242-z.png)
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Abstract
En 中文
The ideal wound care materials for wilderness first aid should be convenient for storage, easy to use, adhesive, antibacterial, anti-inflammatory, pro-angiogenic, wound-closure promoting, and simple for clinical translation. To meet all requirements, we developed a supramolecular FPC hydrogel by simply co-assembling 2-amino-2 '-fluoro-2 '-deoxyadenosine (FA), polydeoxyribonucleotide (PDRN), and collagen III (COL-III)-fully active pharmaceutical ingredients. Based on the abundant hydrogen bonding interactions among FA, PDRN, and COL-III, this hydrogel exhibited sprayability, tissue adhesiveness, and superior biological performance. In vivo studies showed that due to synergistic effects among FA, PDRN, and COL-III, FPC hydrogels offered significant anti-inflammatory benefits and angiogenic capabilities, which promoted granulation tissue formation, collagen deposition, wound tissue epithelialization, and effectively sped up wound healing. Furthermore, the FPC hydrogel could be conveniently stored in a bottle and sterilized through boiling, making it well-suited for wilderness first aid applications. This hydrogel has the potential to transform wound care by offering a versatile solution for both outdoor and everyday wound management needs.
Keywords:
Sprayable wound dressing
Supramolecular hydrogel
Wilderness first aid
Anti-inflammatory
Angiogenesis
Journal
C
IF:
9.2
Papers:
27
Citations:
0